Sample size calculation for finding unseen species
نویسندگان
چکیده
منابع مشابه
Sample Size Calculation for Comparing Means
Sample size calculation plays an important role in clinical research. In clinical research, a sufficient number of patients is necessary to ensure the validity and the success of an intended trial. From a statistical point of view, if a clinically meaningful difference between a study treatment and a control truly exists, such a difference can always be detected with an arbitrary power as long ...
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In clinical research, in addition to continuous responses, primary clinical endpoints for assessment of efficacy and safety of a drug product under investigation could be binary responses. For example, in cancer trials, patients’ clinical reaction to the treatment is often classified as response (e.g., complete response or partial response) or nonresponse. Based on these binary responses, the p...
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In practice, the variabilities of responses involved in clinical research can be roughly divided into three categories. They are, namely, intra-subject, inter-subject, and total variabilities (1). More specifically, the intrasubject variability is the variability observed by repeated measurements on the same subject under exactly the same experiment conditions. This type of variability is very ...
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In most areas in life, it is difficult to work with populations and hence researchers work with samples. The calculation of the sample size needed depends on the data type and distribution. Elements include consideration of the alpha error, beta error, clinically meaningful difference, and the variability or standard deviation. The final number arrived at should be increased to include a safety...
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Addressing a sample size is a practical issue that has to be solved during planning and designing stage of the study. The aim of any clinical research is to detect the actual difference between two groups (power) and to provide an estimate of the difference with a reasonable accuracy (precision). Hence, researchers should do a priori estimate of sample size well ahead, before conducting the stu...
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ژورنال
عنوان ژورنال: Bayesian Analysis
سال: 2009
ISSN: 1936-0975
DOI: 10.1214/09-ba429